The enigma of sepsis.

The Luteal Phase after GnRHa Trigger-Understanding An Enigma

The role of natural killer cells in the pathogenesis of sepsis: the ongoing enigma

The study by Souza-Fonseca-Guimaraes and colleagues in the previous issue of Critical Care shows several alterations in blood natural killer (NK) characteristics during human sepsis and systemic inflammatory response syndrome, including changes in NK cell numbers, Toll-like receptor (TLR) expression, and responsiveness to TLR agonists. This paper advances our knowledge of NK cell biology during...

The Enigma of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Infection in Iran

Human T-cell lymphotropic virus type-I (HTLV-I) was the first human retrovirus associated with malignancy.  The prevalence of HTLV-I infection varies significantly in different regions of the world.  In this study, the prevalence of HTLV-I infection among ethnic Jews living in Shiraz, South of Iran, was investigated. 286 blood samples were obtained.  HTLV-1 antibody assay on serum samples was d...

Statins and sepsis: good bullet, disappearing target.

Despite several decades of research and phenomenal advances in technology and therapeutics, sepsis remains a catastrophic enigma. As a frequent cause of death, sepsis now rivals acute myocardial infarction. The longstanding therapeutic principles of early antibiotics use and supportive care have been difficult to improve upon. The authors conducted a concise review of pertinent literature on th...

Incidence of thrombocytopenia and changes in various platelet parameters, in blood culture positive neonatal sepsis

Abstract Objective: To assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. Methods: This was prospective study conducted over a period of one year from December 2009 to November 2010 in neonatal intensive care unit of DDUH Hospital, a tertiary care hospital in Delhi, North India. All babies who were admitted during this perio...